Santa Maria di Leuca, often spelled simply Leuca, is a frazione of the comune of Castrignano del Capo, in the province of Lecce (Apulia), southern Italy.
A part of the town once belonged to the comune of Gagliano del Capo.
Santa Maria di Leuca is famous for its lighthouse, which, with its height of 48 m and its position at 102 nbps; meters of the sea level, is one of the most important ones in Italy. Next to the lighthouse is the large Sanctuary, or Basilica, De Finibus Terrae ("End of the Land", 1720-1755), built to commemorate the passage of St. Peter here during his travel to Italy. It lies on the former site of a Roman temple dedicated to Minerva. The edifice has a fortified structure, and during its existence it sustained several assault by Turk pirates. In the same site, a Corinthian column was erected in 1939 to celebrate the construction of the Apulian Aqueduct (Acquedotto Pugliese). The basilica is connected to the port through a 184-step staircase.
Punta Meliso promontory is traditionally considered the lowest point of the geographical "heel" of Italian peninsula, as well as the meeting point of the waters from the Adriatic Sea and the Ionian Sea.
Since October 2006 its territory is part of the Regional Park "Costa Otranto - Santa Maria di Leuca e Bosco di Tricase". Santa Maria di Leuca's littoral is marked by numerous grottoes with Latin and Greek inscriptions. Also famous are the 19th century patrician villas (c. 43 in number).
Not far off Punta Ristola, at c. 85 m of depth, lies the shipwreck of the Italian submarine Pietro Micca, sunk during World War II with its crew of 58 men.